Educational guide · Pharmacy testing
NAD+ nasal spray certificate of analysis: what a 4,500 mg COA shows
Published
4,500 mg is the total amount of NAD+ in a 300 mg/mL × 15 mL bottle (300 × 15 = 4,500). A certificate of analysis (COA) is a test report for one batch, or lot. A pharmacy COA, when one exists, is tied to a lot number, which is not the same thing as a research-use-only seller’s marketing COA. This page explains what a COA typically shows. It doesn’t quote any Vivo or VialsRX result.
What 4,500 mg means
A nasal spray label usually states a concentration, in milligrams per milliliter, and a volume. Multiply the two for the total in the bottle: 300 mg/mL × 15 mL = 4,500 mg. That total describes the bottle, not a dose. How much you use, and how often, is set by your provider’s prescription.
The NAD+ Nasal Spray page lists the 300 mg/mL × 15 mL fill along with 300 mg/mL × 30 mL and 150 mg/mL × 15 mL fills, so 4,500 mg isn’t the only bottle. See /nad for each fill’s details.
What a certificate of analysis is
A certificate of analysis is a document reporting test results for one batch, or lot. It’s typically matched to the lot number printed on a label, so the report and the bottle can be connected.
A pharmacy’s lot COA and a research-use-only seller’s published “COA library” are different documents. A seller’s posted COA may not show which lot it covers, and it isn’t tied to a prescription or a pharmacy label. For any COA, the useful question is whether its lot number matches the one on the label in front of you.
What a COA for a compounded NAD+ nasal spray may show
Fields vary by lab and by preparation. A COA for a compounded preparation typically identifies:
- Identity. Which active ingredient the lab found.
- Potency. How the measured amount compares with the amount stated on the label (the label claim).
- Lot. The lot number the report covers, and when the testing was done.
- Other tests, where applicable. Some preparations are also tested for things like endotoxin or sterility, depending on the preparation and the pharmacy’s procedures.
This list describes common fields, not any pharmacy’s panel. It isn’t a statement of which tests VialsRX runs, and it gives no acceptance ranges.
How to ask about testing for a fill
If you have a question about testing for a fill, ask the dispensing pharmacy identified on your prescription label. Pharmacies differ in what they can share.
Have the lot number from your label ready when you ask.
What a COA doesn’t tell you
A COA reports what a lab measured in one lot. It isn’t FDA approval: compounded medications are not FDA-approved, and FDA does not review them for safety, effectiveness, or manufacturing quality before they are dispensed (FDA’s compounding questions and answers). A COA also says nothing about what a medication does.
For general background, see compounding pharmacy safety and how to verify a pharmacy license on the Vivo blog.
Frequently asked questions
What is a certificate of analysis (COA)?
A test report for one batch, or lot, of a product. It is typically matched to the lot number printed on a label.
What does 4,500 mg mean for NAD+ nasal spray?
It’s the total amount in the bottle: 300 mg/mL × 15 mL = 4,500 mg. It describes the bottle, not a dose. Your provider’s prescription sets how much you use.
What should a COA typically list?
Commonly the active ingredient’s identity, potency against the label claim, and the lot number, plus other tests, such as sterility, where they apply. Fields vary by lab and by preparation.
Is a pharmacy COA the same as a research-use-only seller’s COA?
No. A pharmacy COA, when one exists, covers a lot the pharmacy prepared. A research-use-only seller’s posted COA isn’t tied to a prescription or a pharmacy label. Check whether any COA’s lot number matches your label.
How do I ask about testing for my fill?
Ask the dispensing pharmacy identified on your prescription label, and have your lot number ready. Pharmacies differ in what they can share.
Is compounded NAD+ nasal spray FDA-approved?
No. Compounded medications are prepared by licensed pharmacies for individual prescriptions and are not FDA-approved drug products. FDA does not review them for safety, effectiveness, or manufacturing quality before they are dispensed.
Prescription required. Subject to provider approval. Compounded medications are not FDA-approved. This guide is educational and isn’t medical advice.
Sources
- Compounding and the FDA: Questions and Answers — U.S. Food and Drug Administration
- Terms of Service — Vivo Health LLC