Educational guide · Regulatory status & process
Prescription NAD+ vs NMN and NR supplements: how they differ
Published
Prescription NAD+ at Vivo is a compounded medication that requires an online intake, licensed provider review, and a prescription, and is prepared by a licensed compounding pharmacy. NMN and NR are sold over the counter as dietary supplements. This guide compares regulatory status, access, oversight, format, and cost only. Compounded medications are not FDA-approved.
This guide doesn’t compare how well any of these products work, and it doesn’t make claims about what supplements do or don’t do. It covers practical, factual differences: how each category is regulated, how you get it, who is involved, what form it comes in, and what Vivo charges. It isn’t dosing advice or a recommendation.
| Prescription NAD+ at Vivo | NMN or NR supplements | |
|---|---|---|
| Category | Compounded prescription medication | Dietary supplement sold over the counter |
| How you get it | Online intake, licensed provider review, and a prescription if appropriate | Bought directly from a retailer; no prescription |
| Who prepares it | VialsRX, a state-licensed U.S. 503A compounding pharmacy, for your individual prescription | The supplement’s manufacturer or brand |
| Regulatory framework | Pharmacy compounding laws; compounded medications are not FDA-approved | Regulated by FDA as dietary supplements, which are not approved by FDA before they’re sold |
| Clinical oversight | A provider reviews your intake and writes directions for use | None required to purchase |
| Format | Nasal spray, injection, or face cream | Typically capsules, tablets, or powders, per product label |
| Directions | Written by your provider on the prescription label | Per the product label |
| Price at Vivo | See “What prescription NAD+ costs at Vivo” below | Vivo doesn’t sell supplements |
This table compares regulatory status and logistics only. It doesn’t compare effectiveness or safety, and it makes no claims about either category’s effects.
How the regulatory status differs
Compounded prescription medications are prepared by a licensed pharmacy for one individual’s prescription. They are not FDA-approved drug products, and FDA does not review them for safety, effectiveness, or manufacturing quality before they are dispensed. They can only be dispensed with a prescription.
Dietary supplements are a separate category under federal law. Manufacturers are responsible for their products and labels, and supplements are not approved by FDA before they’re sold. No prescription is needed to buy them.
How you get prescription NAD+ at Vivo
Supplements are bought directly, like other over-the-counter products. Prescription NAD+ at Vivo goes through a provider first:
- Online intake. You complete a health-history form online at vivoclinic.org/start.
- Provider review. A licensed provider reviews your intake. Review is asynchronous by default. Some states require a synchronous visit, and a video visit may be required if clinically indicated.
- Prescription, if appropriate. Your provider decides whether a prescription for NAD+ is appropriate for you. If it isn’t, no prescription is issued, and you are not charged for medication. Entering payment information at checkout authorizes your payment method — it does not capture a charge. A charge is captured only after a provider approves the prescription.
- Licensed compounding pharmacy. If prescribed, your medication is prepared and dispensed by VialsRX, a state-licensed U.S. 503A compounding pharmacy, with directions for use written by your provider.
- Shipping and ongoing care. Your prescription ships free with discreet 2-day shipping. You can message your care team after delivery. There’s no minimum term, and you can cancel anytime from your dashboard or by emailing care@vivoclinic.org.
Tell your provider what you already take
If you take any supplements, including NMN or NR, list them on your intake. Your provider reviews your full history and decides whether a prescription, if any, is appropriate.
| Product | First month | Then | Quarterly plan |
|---|---|---|---|
| NAD+ Nasal Spray, 300 mg/mL × 15 mL | $119 | $129/month | — |
| NAD+ Nasal Spray, 300 mg/mL × 30 mL | $139 | $209/month | — |
| NAD+ Nasal Spray, 150 mg/mL × 15 mL | $135 | $159/month | $120/month, billed $359 every 3 months |
| NAD+ Injection | $149 | $199/month | $133/month with quarterly plan |
| NAD+ Face Cream | $119 | $129/month | $83/month with quarterly plan |
Pricing may change, so check /nad, /nad-injection, /nad-cream, and your checkout disclosure for the current price.
Checkout accepts HSA and FSA cards. Accepting a card doesn’t mean your plan will treat the purchase as an eligible expense. Your plan administrator decides that.
Frequently asked questions
What’s the difference between prescription NAD+ and NMN or NR supplements?
They’re different regulatory categories. Prescription NAD+ at Vivo is a compounded medication that requires provider review and a prescription, and is prepared by a licensed compounding pharmacy. NMN and NR are sold over the counter as dietary supplements, without a prescription.
Is prescription NAD+ better than NMN or NR?
Vivo doesn’t compare how well these products work. This guide covers regulatory status, how you get each one, oversight, format, and cost. Whether a prescription is appropriate for you is a decision your provider makes after reviewing your intake.
Do I need a prescription for NMN or NR?
No. NMN and NR are sold as dietary supplements and don’t require a prescription. Prescription NAD+ at Vivo does require licensed provider review and a prescription.
Is compounded NAD+ FDA-approved?
No. Compounded medications are prepared by licensed pharmacies for individual prescriptions and are not FDA-approved drug products. FDA does not review them for safety, effectiveness, or manufacturing quality before they are dispensed.
Should I tell my provider if I take NMN or NR?
Yes. List all supplements you take on your intake so your provider can review your full history.
How much does prescription NAD+ cost at Vivo?
As of October 17, 2026, NAD+ Nasal Spray 300 mg/mL × 15 mL is $119 for the first month, then $129/month. Other sizes, NAD+ Injection, and NAD+ Face Cream are priced on their product pages. There’s no minimum term, and you can cancel anytime.
What happens if I’m not approved?
No prescription is issued, and you are not charged for medication. Entering payment information at checkout authorizes your payment method — it does not capture a charge. A charge is captured only after a provider approves the prescription.
Can I use an HSA or FSA card?
Vivo’s checkout accepts HSA and FSA cards. Whether a purchase counts as an eligible expense is decided by your plan administrator, not by Vivo.
Prescription required. Subject to provider approval. Compounded medications are not FDA-approved. This guide is educational and isn’t medical advice.
Sources
- Compounding and the FDA: Questions and Answers — U.S. Food and Drug Administration
- FDA 101: Dietary Supplements — U.S. Food and Drug Administration
- Terms of Service — Vivo Health LLC